Antigliadin antibodies (AGAs) are antibodies of the IgA and IgG classes found in the serum of celiac disease patients. These antibodies mainly target gliadin-derived peptides, which are the main proteins of gluten. AGAs are not specific for celiac disease as they are also found in patients with other gastrointestinal diseases such as gastritis, gastroenteritis, and IBD.
Their measurement has been used particularly as a screening test. The sensitivity and specificity of these tests approach 90%. False positive results limit their use as a definitive diagnostic test.
References:
- Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1352053/
-
Anti-Gliadin Antibodies Identify Celiac Patients Overlooked by Tissue Transglutaminase Antibodies, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3764583/
-
CELIAC (COELIAC) DISEASE, P.D. Howdle, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003
Disclaimer:
The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.
HealthMatters.io - Lab results explained 