Biomarkers

What is Beta Globulin, Serum?

Protein in the serum is made up of albumin (∼ 60%) and globulin. Together with albumin, globulin forms the total protein level on a blood test lab report. It includes carrier proteins, enzymes, clotting factors, and, predominantly, antibodies.

Globulin is categorized into three main groups:

Beta Globulins

While alpha globulins and beta globulins are primarily transport proteins, gamma globulins are mainly comprised of immunoglobulins (Igs), also known as antibodies.

The major carrier beta globulins are Transferrin and Sex hormone-binding globulin

Beta globulin has a target range of 0.7 – 1.3 g/dL.

Increased Beta Globulins:

  • Hypercholesterolemia (which can occur by itself or in association with biliary cirrhosis, hypothyroidism, or nephrosis): Beta lipoprotein is a beta globulin and is increased in hypercholesterolemia.
  • Iron-deficiency anemia: Transferrin is a beta globulin and is increased in this form of anemia.
  • Estrogen therapy: Estrogen causes increased production of these proteins.

Decreased Beta Globulins:

  • Malnutrition: Transferrin is a beta globulin and is decreased in malnutrition.
  • Consumptive coagulopathy: Several proteins used in the coagulation process are beta globulins. They are consumed in disorders of unrestricted coagulation.

References: 

Serum Albumin and Globulin, https://www.ncbi.nlm.nih.gov/books/NBK204/ 

Disclaimer: 

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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