Biomarkers

What is Pyruvic Acid (Organic Acids)?

Pyruvic Acid feeds into the citric acid cycle & converts into acetyl CoA. Pyruvate is formed from carbohydrate via glucose or glycogen & secondarily from fats (glycerol) & glycogenic amino acids. Pyruvic acid is also formed from lactic acid with O2 and zinc.

Nutrient Associations:

Vitamins B1, B3, B5, Lipoic acid

Metabolic Pathway:

Anaerobic energy production

High levels:

Elevated by a number of nonspecific factors, including vigorous exercise, bacterial overgrowth of the GI tract, shock, poor perfusion, B-vitamin deficiency, mitochondrial dysfunction or damage, and anemia, among others.

Pyruvate may be elevated when B-vitamins, particularly B1 and B5, are insufficient. When both L-Lactate and pyruvate are high, there may be insufficient lipoic acid, a type of B-vitamin. Lipoic acid is an important antioxidant, so low levels can lead to aging-related illnesses. Many studies have shown that lipoic acid is helpful in treating diabetes and for assisting the liver with removing toxins from the body.

Possible causes:

  • Impaired metabolism due to cofactor insufficiencies or toxic metals (As, Pb, Hg, Cd)
  • Muscle injury
  • Severe adrenal insufficiency (impaired conversion of pyruvate to alanine

Additional investigations:

  • Vitamins & Minerals Analysis
  • Comprehensive Urine Elements Profile
  • Adrenal Hormone Profile

Treatment considerations:

  • Supplement cofactors (B1, B2, B3, B5, Mg, Lipoic acid)
  • Remove toxic metals
  • Adrenal support if required

Low levels:

Possible causes:

  • Deficient substrate for energy production
  • Impaired production from glycogen (glycogenolysis), carbohydrates (glycolysis), or proteins (gluconeogenesis)

Additional investigations:

  • Urinary Amino Acids
  • Vitamin & Mineral Analysis
  • Adrenal Hormone Profile

Treatment considerations:

  • Gluconeogenic amino acids (e.g. L-alanine, glycine, L-serine)
  • B6, Mg
  • Correct glucose/insulin imbalances
  • Adrenal support if required
  • Consider Ca pyruvate supplementation

Disclaimer:

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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