What is Homovanillate?

Homovanillate (aka Homovanillic Acid) is a dopamine metabolite.

Links to biomarker from different labs:

Homovanillate and Vanilmandelate are breakdown products from neurotransmitters involved in hormone and nerve impulse transmission, called catecholamines.

homovanillate metabolite dopamine healthmatters treatment meaning high low

High levels:

Elevations of Homovanillate and Vanilmandelate indicate an over-activation of nervous system function involving these neurotransmitters. This can be for various reasons, but is most commonly associated with stress, both internal (e.g., mental/emotional) and external (e.g., environmental toxins). Addressing the source of stress and improving the body’s ability to handle stress are useful in these cases.

Possible causes:

  • Increased catecholamine activity/stress pattern
  • Impaired production of noradrenalin from dopamine

Additional investigations:

  • Adrenal Hormone Profile

Treatment considerations:

  • Adrenal support
  • Stress management

Low levels:

When these compounds are low, it indicates your body is not making enough of these neurotransmitters. Low Homovanillate indicates low levels of dopamine. Symptoms associated with this condition are depression, sleep disturbances, inability to deal with stress, and fatigue.

Possible causes:

  • Low precursors/neurotransmitters (phenylalanine, dopamine, noradrenalin)
  • Low cofactors (B2, B3, B6, Mg or Fe)
  • Impaired methylation

Additional investigations:

  • Vitamins & Minerals Analysis

Treatment considerations:

Treatments to improve digestion, along with supplementation of tyrosine or phenylalanine, can help improve the ability to keep up with demand for these neurotransmitters.

  • L-tyrosine & B6
  • B2, B3 or Fe if low
  • Support methylation (methionine/SAMe, B6, B12, folate, Mg)


The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.


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