Glutathione (GSH) is a tripeptide made up of Glutamine, Glycine, and Cysteine and is the body’s most potent endogenous antioxidant. Glutathione plays a central role in resistance to oxidative stress, functioning as an intracellular antioxidant, as well as a detoxifying agent for many xenobiotics.
Low levels:
Low Glutathione contributes to oxidative stress and is thus a risk factor for many chronic diseases.
Low Glutathione is associated with:
- Reduced antioxidant capacity, increased risk of oxidative damage and chronic illness
- Reduced ability to detoxify environmental toxins & metabolic byproducts
- Compromised gut lining, altered immunity, & reduced exercise endurance
- Reduced SAMe synthesis & methylation
Treatment Options to increase Glutathione:
Dietary adjustments:
Increase: diet protein, fresh fruits & vegetables
Supplementation considerations:
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- Digestion support
- Glutathione and/or its building blocks & cofactors
- L-methionine
- NAC
- L-glutamine
- Glycine, serine
- Mg
- B2, B6
- B12, folic acid
Additional supportive nutrients:
- Vitamins C & E,
- Plant-based anti-oxidants
- Pantothenic acid (B5)
- Selenium & Zn
- Bioflavonoids
Prevent GSH depletion:
Avoid high-fat diets, cigarette smoke, infection or inflammation, toxic exposure; consider Vitamins C & E, alpha lipoic acid, milk thistle, taurine, ginkgo biloba, curcumin.
Further Evaluation:
- Nutritional: Amino Acid Analysis, ONE, or NutrEval
- Gastrointestinal: CDSA 2.0, Celiac Profile
High levels:
Higher Glutathione is associated with:
- Efficient GSH synthesis
- Supplementation with GSH or its precursors
- L-cysteine or
- N-acetylcysteine (NAC),
- Glycine,
- L-glutamine)
Disclaimer:
The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.
