What is Glutathione?

Glutathione (GSH) is a tripeptide made up of Glutamine, Glycine, and Cysteine and is the body’s most potent endogenous antioxidant. Glutathione plays a central role in resistance to oxidative stress, functioning as an intracellular antioxidant, as well as a detoxifying agent for many xenobiotics.

glutathione healthmatters genova dutch high low meaning treatment symptoms

Low levels:

Low Glutathione contributes to oxidative stress and is thus a risk factor for many chronic diseases.

Low Glutathione is associated with:

  • Reduced antioxidant capacity, increased risk of oxidative damage and chronic illness
  • Reduced ability to detoxify environmental toxins & metabolic byproducts
  • Compromised gut lining, altered immunity, & reduced exercise endurance
  • Reduced SAMe synthesis & methylation

Treatment Options to increase Glutathione:

Dietary adjustments:

Increase: diet protein, fresh fruits & vegetables

Supplementation considerations:

  • Digestion support
  • Glutathione and/or its building blocks & cofactors
  • L-methionine
  • NAC
  • L-glutamine
  • Glycine, serine
  • Mg
  • B2, B6
  • B12, folic acid

Additional supportive nutrients:

  • Vitamins C & E,
  • Plant-based anti-oxidants
  • Pantothenic acid (B5)
  • Selenium & Zn
  • Bioflavonoids

Prevent GSH depletion:

Avoid high-fat diets, cigarette smoke, infection or inflammation, toxic exposure; consider Vitamins C & E, alpha lipoic acid, milk thistle, taurine, ginkgo biloba, curcumin.

Further Evaluation:

  • Nutritional: Amino Acid Analysis, ONE, or NutrEval
  • Gastrointestinal: CDSA 2.0, Celiac Profile

High levels:

Higher Glutathione is associated with:

  • Efficient GSH synthesis
  • Supplementation with GSH or its precursors
    • L-cysteine or
    • N-acetylcysteine (NAC),
    • Glycine,
    • L-glutamine)


The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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