What is Aspartic Acid (Genova)? High and low values | Lab results explained

Aspartic acid is a nonessential protein amino acids. Aspartic Acid, also known as aspartate, is an excitatory neurotransmitter in the brainstem and spinal cord. Aspartic acid is the excitatory counterpart to glycine, an inhibitory neurotransmitter.

Lower levels:

Low levels have been linked to feelings of fatigue and low mood, whereas high levels have been linked to seizures and anxiousness.

  • Inhibits ammonia detoxification in the urea cycle. Can be converted to oxaloactetate using B6 and α-KG and thus enter the Krebs cycle.
  • Low levels can reflect decreased cellular energy generation, seen as fatigue. Citric and aspartic acids can drive the Krebs (citric acid) cycle, when combined with B6 and α-KG.

Higher levels:

Sometimes seen in epilepsy and stroke. Magnesium and zinc may counteract high aspartic add levels.


The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.


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