Ornithine is a urea cycle metabolite.
Ornithine can stimulate the release of growth hormone. Growth hormone is necessary for tissue repair and growth. Growth hormone is often low in patients with fibromyalgia.
Ornithine elevation may indicate a higher body burden of ammonia. Alpha-ketoglutarate and vitamin B6 may aid in clearing chronic minor excesses of ammonia.
Higher levels:
A possible metabolic block in urea cycle, causing excess ammonia burden. Confirm by checking for high glutamine, low glutamic acid.
Alpha-ketoglutarate and vitamin B6 may aid in clearing chronic minor excesses of ammonia.
Lower levels:
Possibly due to low arginine, as it is synthesized from arginine. As a source of regulatory polyamines, a low can affect cellular metabolism.
References:
– https://www.ncbi.nlm.nih.gov/pubmed/19083482
– https://www.ncbi.nlm.nih.gov/pubmed/27978498
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