Ornithine is a urea cycle metabolite.
Higher levels:
A possible metabolic block in urea cycle, causing excess ammonia burden. Confirm by checking for high glutamine, low glutamic acid.
Alpha-ketoglutarate and vitamin B6 may aid in clearing chronic minor excesses of ammonia.
Lower levels:
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Possibly due to low arginine, as it is synthesized from arginine. As a source of regulatory polyamines, a low can affect cellular metabolism.
References:
– https://www.ncbi.nlm.nih.gov/pubmed/19083482
– https://www.ncbi.nlm.nih.gov/pubmed/27978498
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