Thyrotropin Receptor Ab, Serum is used for the diagnosis of hyperthyroidism and Graves’ disease.
Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves’ disease, and is the cause of the hyperthyroidism of that condition. The characterization of Thyrotropin Receptor antibody resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems.
These antibodies are present in 50% of euthyroid Graves’ disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves’ disease. Detection of these antibodies is useful in prediction of neonatal hyperthyroidism and prediction of relapse of hyperthyroidism.
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
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