Thyrotropin Receptor Ab, Serum is used for the diagnosis of hyperthyroidism and Graves’ disease.
Thyrotropin-receptor antibody is an autoantibody to the thyroid cell receptor for thyroid-stimulating hormone. It can be demonstrated in 90% of patients with Graves’ disease, and is the cause of the hyperthyroidism of that condition. The characterization of Thyrotropin Receptor antibody resolved much confusion about long-acting thyroid stimulator (LATS) and LATS protector, which are both, in fact, thyroid-stimulating autoantibodies which simply behaved differently in animal test systems.
Higher values:
These antibodies are present in 50% of euthyroid Graves’ disease as well as hyperthyroid patients. They play a major role in the pathogenesis of Graves’ disease. Detection of these antibodies is useful in prediction of neonatal hyperthyroidism and prediction of relapse of hyperthyroidism.
References:
https://www.ncbi.nlm.nih.gov/pubmed/29771756
https://www.ncbi.nlm.nih.gov/pubmed/1633635
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Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
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