Biomarkers

Androgens and Metabolites (Urine) – DUTCH — Interpretation of DUTCH test (Dried Urine Test) from Precision Analytics (PART 3)

In the Androgens and Metabolites section of the DUTCH test we are looking at essentially three main things:

androgens and metabolites dhea-s androsterone etiocholanolone testosterone 5a-androstanediol 5a-DHT 5b-androstanediol epi-testosterone

1. Total DHEA production

2. Testosterone levels

3. Metabolic preference (5a versus 5b metabolism)

– If androgens are heading down the alpha pathway, there is more of a preference for making DHT, which is highly androgenic

1. Total DHEA production

To look at the total DHEA production we are adding up the three primary DHEA metabolites:

– DHEA-S (The “S” stands for sulfate)

– Etiocholanolone

– Androsterone

If you are adding those 3 metabolites of DHEA together we are getting a good picture of the Total DHEA production for the day.

Why are we looking at those 3 metabolites? If, for example, overall DHEA levels and Etiocholanolone + Androsterone are high, why could DHEA-S levels be low? Inflammation could be blocking the sulfation of DHEA. So, it’s good to look at the various DHEA markers instead of just looking at one overall DHEA level.

2. Testosterone levels

There is simply a single measurement of testosterone. The measurements also include 3 downstream metabolites of testosterone:

– 5a-DHT

– 5a-Androstanediol

– 5b-Androstanediol

3. Metabolic preference (5a versus 5b metabolism)

– Androsterone is a 5a-metabolite

– Etiocholanolone is a 5b-metabolite

If Androsterone is elevated and Etiocholanalone is relatively low, the metabolism will tend to favor towards the alpha side. Alpha metabolites are more androgenic and beta metabolites are less androgenic.

When testosterone pushes towards DHT it has to go down the 5-alpha metabolite pathway. This can be the case in a female with, for example, PCOS. In this situation there is typically an insulin issue which pushes towards 5-alpha. When testosterone gets into the cellular space (ex. hair follicle or skin) it will shift towards DHT (via the 5-alpha pathway). DHT happens to be 3-times more potent than testosterone. In these women symptoms of high androgen, such as thinning scalp hair, facial hair growth or acne can often show.

To summarize, in this category we have to look at the overall DHEA levelsTestosterone levels and the metabolic preference (alpha versus beta). If androgens are heading down the 5a pathway, there is more of a preference for making DHT (very androgenic). This can even happen if overall androgen levels are low.

5a-Androstanediol

 Optimal range: 12 – 30 ng/mg

5a-Androstanediol is a testosterone metabolite that is more androgenic than b-Androstanediol. It is metabolized via the 5-alpha metabolic pathway (= increased 5α-reductase activity). In contrast, the 5-beta metabolism makes androgens less potent.

Increased 5a-reductase activity may be accompanied by clinical signs of androgenicity (excess facial hair growth, scalp hair loss, acne, irritability, oily skin, prostate issues in men…etc).

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5a-DHT

 Optimal range: 0 – 6.6 ng/mg

5a-DHT is a testosterone metabolite. 

5a-DHT is essential for the development of the male sex characteristics before birth, particularly the formation of the external genitalia. In the adult, 5a-DHT is needed to develop and maintain male gender characteristics, such as facial hair, deep voice, and muscle growth. In women, 5a-DHT may induce the onset of puberty and causes the body and pubic hair growth.

Increased 5a-DHT levels are found in about 40% of patients with idiopathic hirsutism and 35% of patients with polycystic ovarian syndrome (=PCOS).

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5b-Androstanediol

 Optimal range: 20 – 75 ng/mg

5b-Androstanediol is a testosterone metabolite that is less androgenic than 5a-DHT and 5a-Androstanediol. It is metabolized via the 5-beta metabolic pathway. In contrast, the 5-alpha metabolism makes androgens more potent (= increased 5α-reductase activity).

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Androsterone

 Optimal range: 200 – 1650 ng/mg

Androsterone is a DHEA metabolite via the 5-alpha-reductase pathway. The 5-alpha pathway is more androgenic.

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DHEA-S (Urine)

 Optimal range: 20 – 750 ng/mg

DHEA-S is the sulfate ester of DHEA and only a part of DHEA testing. If this marker was low it would mean that there is potential inflammation blocking DHEA being converted to DHEA-S.

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Epi-Testosterone

 Optimal range: 2.3 – 14 ng/mg

Epi-Testosterone is one of several naturally-occurring testosterone compounds in the body that act as steroids.

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Etiocholanolone

 Optimal range: 200 – 1000 ng/mg

Etiocholanolone is a DHEA metabolite that is excreted in the urine. It is produced from androstenedione and the 5-beta-reductase metabolic pathway. It is helpful in evaluating adrenal and androgen function.

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Testosterone (DUTCH)

 Optimal range: 2.3 – 14 ng/mg

Testosterone is the major androgen in the body. It is converted to dihydrotestosterone by 5-alphareductase, and to estradiol by aromatase.

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Total DHEA Production

Optimal range: 400 – 3000 ng/mg

DHEA is often called the anti-aging hormone. It’s made in the adrenal glands naturally and levels hit their peak in your 20s. They start to dwindle after you hit 30. Estrogen and testosterone are created from DHEA.

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Disclaimer:

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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