Lipid Peroxides (urine) is an oxidative stress marker.
Lipid Peroxides are a direct indicator of oxidative damage to polyunsaturated fatty acids (PUFAs), suggesting that production of reactive oxygen species (=ROS) has been inadequately balanced by antioxidants, esp. fat-soluble. Lipid peroxidation in cell membranes results in cellular dysfunction and is increased in many disease states. Lipid Peroxides are also increased in tissues that are poisoned by toxins.
Concentrations of lipid peroxides may be measured in urine or serum, but serum has superior sensitivity to slight increases in lipid peroxidation. It has gained general acceptance in research and clinical laboratory as a standard means of assessing the body’s antioxidant capability and overall oxidative stress.
Whenever total antioxidant capacity is inadequate to meet the oxidative challenge, cell membrane oxidation increases, releasing lipid peroxides.
What is Oxidative Stress?
Oxidative Stress occurs when the production of reactive oxygen species (ROS) outweighs the body’s ability to remove them, thus shifting this equilibrium in the direction of oxidation (=rusting). The instability of free radicals and other ROS causes them to extract electrons from neighboring molecules in a chain reaction, causing cellular damage in the process. Oxidative stress has an integral relationship with the inflammatory cascade, which produces ROS, and is considered a driving force in the aging process.
Oxidative stress has been implicated in a growing list of disorders, including:
– macular degeneration,
– chronic fatigue syndrome,
– and neurodegenerative diseases.
Normal Lipid Peroxides would suggest that despite potential oxidative stress, oxidative damage has not yet occurred.
Though, oxygen is imperative for life, imbalanced metabolism and excess reactive oxygen species (ROS) generation end into a range of disorders such as Alzheimer’s disease, Parkinson’s disease, aging and many other neural disorders.
Toxicity of free radicals contributes to proteins and DNA injury, inflammation, tissue damage and subsequent cellular apoptosis.
Also, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty.
High Lipid Peroxides are associated with:
– Oxidative damage to lipids in the body due to excessive reactive oxygen species production.
– Oxidative damage to lipids in the body due to deficient antioxidant protection
– High-fat diet, excess Fe or Cu, smoking, obesity with insulin resistance, heavy metal toxicity, excessive exercise, protein energy malnutrition, periodontitis, chronic disease
– Essential Fat (EMFA) deficiencies (from ROS attack), GSH, B6 (deficiency promotes mitochondrial decay), Mg (required for GSH synthesis), B2 (required for GSH reduction), Zn
– Inadequate vitamin C is one factor leading to elevated lipid peroxides.
– Elevated lipid peroxides may indicate a need for coenzyme Q10.
When prolonged or severe, oxidative stress eventually results in tissue damage and increased risk of disease, as indicated by an elevated Lipid Peroxides (reflecting oxidative damage to lipids in the body).
Treatment options to increase Total Antioxidant Capacity (TAC):
Diet is major source of antioxidants, as well as medicinal herbs are catching attention to be commercial source of antioxidants at present. Recognition of upstream and downstream antioxidant therapy to oxidative stress has been proved an effective tool in alteration of any neuronal damage as well as free radical scavenging.
– Increase: fresh fruits & vegetables
– Eliminate: trans fats
– Eliminate excess Iron or Cu (promotes hydroxyl radical production)
– Antioxidants, esp. fat-soluble: Vitamins A & E, CoQ10, Carotenoids
– Herbal antioxidants: garlic, green tea, curcuma, propolis, grape-seed
– Environmental: Elemental Analysis (urine, RBCs)
– Nutritional: Amino Acid Analysis, Organic Acids
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
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