What is Calprotectin? High and low values | Lab results explained

Calprotectin, a member of the S100 calcium- and zinc-binding protein family, is a protein released by a type of white blood cell called neutrophil. When there is inflammation in the gastrointestinal tract, neutrophils move to the area and release calprotectin, resulting in an increased level in the stool.

The amount of calprotectin reflects the number of participating neutrophils in this inflammation. Calprotectin is most frequently used as part of the diagnostic evaluation of patients with suspected inflammatory bowel disease (IBD).

For the individuals already diagnosed with IBD, it can be used to monitor the level of inflammation.


Five polyphenols in particular have evidence of benefit in treating gut inflammation:

– resveratrol,

– epigallocatechin,

– curcumin,

– quercetin,

– and Boswellia.

Sleep, diet, exercise and stress management should be evaluated.

Be cautious with medications such as ibuprofen, acetaminophen, aspirin, especially in children.


Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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