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Biomarkers

Hypo- and hyper-thyroidism: algorithm for screening and diagnosis

Screening, diagnosing, and managing hypothyroidism:

ATA/AACE guidelines recommend screening for all patients with symptoms of hypothyroidism. For patients who
are asymptomatic, recommendations vary widely. However, a thyroid-stimulating hormone (TSH) test is generally
recommended for patients ≥50–60 years old, especially women.

Guidelines also state that there is compelling evidence to support screening in patients with:

  • Autoimmune disease (e.g., type 1 diabetes)
  • Pernicious anemia
  • Family history
  • History of neck radiation
  • History of thyroid surgery
  • Abnormal thyroid examination
  • Psychiatric disorders, including patients taking amiodarone or lithium
  • Hypertension, cardiac dysrhythmia, or congestive heart failure

Hypothyroidism: algorithm for screening and diagnosis:

Signs or symptoms of hypothyroidism include:

  • Poor memory and concentration
  • Hoarseness
  • Slow pulse rate
  • Delayed reflex relaxation
  • Cold extremities/feeling cold
  • Carpal tunnel syndrome
  • Fatigue
  • Weight gain and poor appetite
  • Hair loss
  • Shortness of breath
  • Constipation

Screening, diagnosing, and managing hyperthyroidism:

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In 2016, the ATA updated the ATA/AACE guidelines for hyperthyroidism, a form of thyrotoxicosis. Updates include
new approaches and changing paradigms for:

  • Evaluating and managing Graves’ disease with antithyroid drugs (ATDs)
  • Managing hyperthyroid patients planning pregnancy
  • Managing calcium metabolism prior to thyroid surgery
  • Re-evaluating the long-term toxicity of antithyroid drugs

The guidelines recommend screening for all patients with symptoms of hyperthyroidism. Once a diagnosis is made,
the etiology should be determined.

Hyperthyroidism: algorithm for screening and diagnosis

Signs or symptoms of hyperthyroidism include:

  • Nervousness or irritability
  • Fatigue/muscle weakness
  • Heat intolerance
  • Trouble sleeping
  • Hand tremors
  • Irregular heartbeat
  • Weight loss
  • Frequent bowel movements/diarrhea
  • Goiter
  • Graves’ ophthalmopathy

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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