Biomarkers

What is Adipate? Definition, Reference Ranges, Interpretation

Adipate, together with Suberate and Ethylmalonate are all functional markers for deficiency of carnitine.

adipate high low meaning reference ranges

What is Carnitine?

Carnitine is needed to move fatty acids into the mitochondria where they are converted to energy using vitamin B2.

If carnitine is sufficient long-chain fatty acids go through beta-oxidation in the mitochondria.

When insufficient levels of carnitine or vitamin B2 slow down this process, other parts of the cellular machinery take over and make adipate and suberate.

adipate ATP energy cycle fatty acid high low meaning

A similar block in another pathway causes high ethylmalonate. Since most of our bodies’ energy is produced from the burning of fatty acids, our muscles and brain suffer when this cellular energy pathway is blocked. Anything that interferes with the normal fatty acid oxidation may reveal high levels of these metabolites.

adipate high low meaning citric acid cycle genova acid test results report

If Adipate is elevated consider supplementing with carnitine and vitamin B2. Carnitine supplementation has been documented to improve Alzheimer’s, age-related cognitive decline, and cardiac function.

3,4 Dihydroxyphenylpropionate

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