Alternative names:
DHPPA, Dihydroxyphenylpropionate
What is 3,4 Dihydroxyphenylpropionate?
3,4-Dihydroxyphenylpropionate seems to be strongly associated with a troublesome type of bacteria called Clostridia.
What is Clostridia?
This organism is frequently the cause of travelers diarrhea, but its by-products may produce other symptoms.
Clostridium species constitute a major portion of the bacteria of the lower ileum and colon. Being strictly anaerobic, they are difficult to culture from stool and are not reported on most stool cultures.
Cases of confirmed Clostridium overgrowth show elevated levels of Dihydroxyphenylpropionate, which fall to baseline with Flagyl treatment, but are unaffected by nystatin.
Further info on Dihydroxyphenylpropionate:
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In health, beneficial intestinal bacteria produce some B-vitamins and provide stimulus for proper immune function. However, if your stomach acid is not adequate, if you fail to digest protein, or if your diet does not supply sufficient fiber, the resulting overgrowth of unfavorable bacteria can release toxic products that your body must remove. These toxic products include Dihydroxyphenylpropionate.
A healthy result should fall into the range 0 – 0.05 mcg/mg creatinine.
Raised levels of this compound indicate overgrowth of Clostridia and /or Pseudomonas.
References:
- https://www.ncbi.nlm.nih.gov/pubmed/19152477
- Laboratory Evaluations for Integrative and Functional Medicine
edited by Richard S. Lord, J. Alexander Bralley, [L]
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