Guide to Intestinal antigenic permeability screen (Cyrex Screen 2)

Interpretation chart of elevated level of antibodies against LPS, Occludin/Zonulin, Actomyosin:

LPS IgA, IgM or IgG+++
Occludin/Zonulin IgA, IgM or IgG++
Actomyosin IgA++
Gut flora imbalanceBreakdown in intestinal barrier integrity by bacterial antigens through paracellular pathwayBreakdown in intestinal barrier integrity by factors other than bacterial antigens, through paracellul pathway arBreakdown in intestinal barrier integrity by bacterial antigens through transcellular pathwayAutoimmunity against mucosal epithelium and hronic other tissue cell cytoskeleton including Celiac disease, C Active Hepatitis and primary biliary cirrhosis
Clinical ApproachPre- & Pro- bioticsPre- & Pro-biotics Heal the gutReduce st ress Heal the gutPre- & Pro- bioticsAnti-inflammatories

Research confirms that the root cause for many of undesired immune reactions originates in the gastrointestinal tract. GI tract abnormality can compromise the integrity of the gut barrier and increases the entry of undigested antigens into the sub-mucosa and the circulation, thus challenging the immune system. Reaction to these antigens activates immune and inflammatory cascades, resulting in the production of pro-inflammatory cytokines and an array of antibodies, which further contributes to increased intestinal barrier permeability (or “leaky gut” syndrome).

Increased permeability of the intestinal barrier to macromolecules is associated with a variety of local and systemic inflammatory conditions. Intestinal permeability can cause systemic inflammation, which can then sustain itself by its ongoing effect on the gut. The target tissue damage is primarily determined by genetics and exposure of environmental factors, leading to various clinical conditions including:

  • Gluten Sensitivity and Celiac disease
  • Food Allergies
  • Inflammatory bowel disease (Ulcerative Colitis and Crohn’s disease)
  • Numerous autoimmune diseases (Rheumatoid Arthritis, Psoriasis, Type 1 Diabetes, Spondylitis, etc.)
  • Neurological conditions (Multiple Sclerosis, Guillain Barré Syndrome, etc.)
  • Cognitive Dysfunction (depression, anxiety, Schizophrenia, etc.)
  • Others


Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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