Biomarkers

What is Methylcitric Acid? High and low values | Lab results explained

Methylcitric is an organic acids that reflects decreased activity of the biotin-dependent enzyme propionyl-CoA carboxylase.

Elevation generally indicates biotin deficiency due to malabsorption, egg white intake, or dysbiosis.

WHAT DOES IT MEAN IF YOUR METHYLCITRIC RESULT IS TOO LOW?

Low values of methylcitric acid have no known significance.

WHAT DOES IT MEAN IF YOUR METHYLCITRIC RESULT IS TOO HIGH?

Elevation usually indicates a biotin deficiency (Vitamin H). 

Biotin deficiency may be due to: 

– malabsorption,

– excessive intake of raw egg white,

– dietary deficiency,

– or dysbiosis. 

Higher levels may also indicate the presence of genetic disorders involving biotin-dependent enzymes and may require biotin supplementation at very high doses. 

However, some studies have shown that Methylcitric is not a reliable marker for biotin deficiency [L].

Disclaimer:

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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