Biomarkers

What is Methylsuccinic? High and low values | Lab results explained

Methylsuccinic – Optimal Result: 0.1 – 2.2 mmol/mol creatinine.

Methylsuccinic acid is a normal metabolite found in human fluids and is an intermediate metabolite in the breakdown of fatty acids. Increased urinary levels of methylsuccinic acid (together with ethylmalonic acid) are the main biochemical measurable features in ethylmalonic encephalopathy.

References:

https://pubmed.ncbi.nlm.nih.gov/29555466/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493831/
https://pubmed.ncbi.nlm.nih.gov/20978941/
https://pubmed.ncbi.nlm.nih.gov/12382164/
https://pubmed.ncbi.nlm.nih.gov/22424739/
https://pubmed.ncbi.nlm.nih.gov/18054510/
https://pubmed.ncbi.nlm.nih.gov/7776094/
https://pubmed.ncbi.nlm.nih.gov/7360517/
https://pubmed.ncbi.nlm.nih.gov/10723193/
https://pubmed.ncbi.nlm.nih.gov/7145508/
https://pubmed.ncbi.nlm.nih.gov/19343532/
https://pubmed.ncbi.nlm.nih.gov/19343532/
https://pubmed.ncbi.nlm.nih.gov/6452974/
https://pubmed.ncbi.nlm.nih.gov/2109491/

WHAT DOES IT MEAN IF YOUR METHYLSUCCINIC RESULT IS TOO HIGH?

Increased urinary levels of methylsuccinic acid (together with ethylmalonic acid) are the main biochemical measurable features in ethylmalonic encephalopathy, a rare metabolic disorder with an autosomal recessive mode of inheritance that is clinically characterized by neuromotor delay, hyperlactic acidemia, recurrent petechiae, orthostatic acrocyanosis, and chronic diarrhea. The underlying biochemical defect involves isoleucine catabolism. 

Other inborn errors:

Moreover, methylsuccinic acid is found to be associated with isovaleric acidemia, and medium-chain acyl-CoA dehydrogenase deficiency, which are also inborn errors of metabolism.

High Methylsuccinic levels may also be due to:

– carnitine deficiency, 
– fasting, 
– increased intake of the medium-chain triglycerides found in coconut oil, MCT oil, and some infant formulas. 

Regardless of cause, supplementation with L-carnitine or acetyl-L-carnitine (500-1000 mg per day) may be beneficial.

Disclaimer:

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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