Prevotella copri is a gut bacteria that may cause rheumatoid arthritis. Studies consistently find different bacterial patterns in people with inflammatory arthritis vs controls. Some of those are high in prevotella copri.
Various studies have linked the increased abundance of Prevotella species at mucosal sites to localized and systemic disease, including:
- periodontitis,
- bacterial vaginosis,
- rheumatoid arthritis,
- metabolic disorders and
- low‐grade systemic inflammation.
The studies show that in control groups a large percentage (75%) of patients that have RA, but hadn’t yet been treated, have Prevotella copri present in their intestines. In another group of patients, with either rheumatoid or psoriatic arthritis, 37% of patients show Prevotella copri and only 21% in healthy controls.
References:
- Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. (https://www.ncbi.nlm.nih.gov/pubmed/27863183)
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Can Prevotella copri Be a Causative Pathobiont in Rheumatoid Arthritis? (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129594/)
- Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. (https://www.ncbi.nlm.nih.gov/pubmed/24192039)
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The immune response to Prevotella bacteria in chronic inflammatory disease (https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12760)
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