Biomarkers

What is Ethylmalonate?

Ethylmalonate, together with Adipate and Suberate, gives information about your ability to process fatty acids.

ehtylmalonate high low meaning treatment test results

Ethylmalonate, which comes from the breakdown of butyrate, has a carnitine-dependent pathway and can accumulate with an insufficient amount of carnitine. Dietary fat, carbohydrate, and protein are all broken down to produce energy using pathways that require vitamin B2 (riboflavin).

If you do not have sufficient riboflavin, compounds such as adipate, suberate, and ethylmalonate may increase in urine.

What is Carnitine?

Carnitine helps your body use fatty acids. The body makes small amounts of carnitine.

However, if minimum requirements are not met, carnitine dependent functions fail to proceed normally. Long-chain fatty acids go through beta-oxidation in the mitochondria, which is a carnitine dependent step.

If there are inadequate amounts of carnitine, the long-chain fatty acids will get processed outside of the mitochondria; Adipate and suberate are by-products of long-chain fatty acid breakdown outside of the mitochondria.

Elevated levels:

Adipate, Suberate, and Ethylmalonate elevations indicate metabolic blocks. Carnitine is needed to move fatty acids into the mitochondria where they are converted to energy using vitamin B2. When insufficient levels of carnitine or vitamin B2 slow down this process, other parts of the cellular machinery take over and make adipate and suberate. A similar block in another pathway causes high ethylmalonate. Since most of your body’s energy is produced from the burning of fatty acids, your muscles and brain suffer when this cellular energy pathway is blocked.

Treatment:

Supplementation of carnitine and vitamin B2 may be needed when these compounds are too high. Insufficiency of vitamin B2 is implicated in impaired carbohydrate metabolism, migraines, and dementia. Carnitine supplementation has been documented to improve Alzheimer’s, age-related cognitive decline, and cardiac function.

References:

Disclaimer:

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.