Biomarkers

What is Sarcosine?

Sarcosine is also known as N-methylglycine.

what is sarcosine genova test results meaning interpretation b2 amino acids glycine metabolite high low

It is an intermediate and byproduct in the glycine synthesis and degradation. Sarcosine is metabolized to glycine by the enzyme sarcosine dehydrogenase, while glycine-N-methyl transferase generates sarcosine from glycine. Sarcosine is a natural amino acid found in muscles and other body tissues. Sarcosine is found naturally as an intermediate in the metabolism of choline to glycine. Sarcosine is a competitive inhibitor of the type I glycine transporter (GlyT1), an N-methyl-D-aspartate receptor (NMDAR) co-agonist, and an important intermediate in one-carbon metabolism.

  • Its therapeutic potential for schizophrenia further underscores its clinical importance.
  • It is currently also being researched as a biomarker for prostate cancer [1, 2, 3, 4].

High levels:

  • Metabolism requires B2. May indicate functional B2 deficiency.
  • Suspect increased need for folic acid if: Elevated HOMOCYSTINE, SARCOSINE, glycine, serine, 1-methylhistidine, 3-methylhistidine, methionine, cystathionine or histidine
  • Could also be Sarcosinemia, a rare autosomal recessive metabolic disorder. It can result from an inborn error of sarcosine metabolism, or from severe folate deficiency. It is thought to be a relatively benign condition.

References:

  1. https://www.ncbi.nlm.nih.gov/pubmed/23880848
  2. https://www.ncbi.nlm.nih.gov/pubmed/26174441
  3. https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.28347
  4. https://www.mdpi.com/1422-0067/14/7/13893/htm

Disclaimer:

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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