What is Malate?

Malate is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism. This cycle critically supports organ maintenance and neurological function.

malate malic acid krebs cycle meaning high low treatment q10 coenzyme

High levels:

  • Higher levels of Malate in urine indicates inefficiencies in energy production.
  • Coenzyme Q10 deficiency causes elevation of this intermediate.

Low levels:

  • A deficiency in one or more Krebs’ cycle intermediates and an inhibition of normal energy production may cause a wide range of metabolic disturbances and symptoms.
  • Low levels can indicate a general amino acid insufficiency.


The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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