Malate is involved in the citric acid cycle (aka. Krebs cycle). The citric acid cycle is a series of reactions that occur in the mitochondrion to generate chemical energy that fuels the metabolism. This cycle critically supports organ maintenance and neurological function.
High levels:
- Higher levels of Malate in urine indicates inefficiencies in energy production.
- Coenzyme Q10 deficiency causes elevation of this intermediate.
Low levels:
- A deficiency in one or more Krebs’ cycle intermediates and an inhibition of normal energy production may cause a wide range of metabolic disturbances and symptoms.
- Low levels can indicate a general amino acid insufficiency.
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