Biomarkers

What is Nonadecanoic Acid? High and low values | Lab results explained

Nonadecanoic Acid is an odd chain fatty acid.

Nonadecanoic acid high meaning treatment b12 vegan gdx genova intgerpretation interpretive functional medicine

Fatty acids with odd numbers of carbon atoms are produced primarily by initiating the synthetic series with the three carbon compound, propionic acid.

Vitamin B12 is required for the conversion of propionate into succinate for oxidation in the central energy pathways.

Deficiency of vitamin B12 results in accumulation of propionate and subsequent buildup of the odd numbered fatty acids, pentadecanoic, heptadecanoic, nonadecanoic, heneicosanoic, and tricosanoic acids.

The bacteria in the gut of ruminants (grazing animals like cows and sheep) produce large amounts of propionate, which is absorbed and enters the metabolism of the animal. High intake of animal and dairy products favor high levels of these fatty acids.

Alternatively, it is possible that the bacteria in the human gut could produce sufficient amounts of propionate to lead to elevation in the odd-carbon fatty acids. This would only occur under conditions of significant gut dysbiosis.

Carnitine is required for fatty acid oxidation. In carnitine insufficiency, fatty acids are oxidized via an omega oxidation pathway that creates odd chain units. Therefore, odd chain fatty acid accumulation may indicate carnitine deficiency and the need for carnitine supplementation.

The odd numbered fatty acids containing 15, 17, 19, or 21 carbon atoms (heptadecanoic acid, nonadecanoic acid, tricosanoic acid, pentadecanoic acid) accumulate in vitamin B12 deficiency.

Higher values:

The bacteria in the gut of ruminants (grazing animals like cows and sheep) produce large amounts of propionate, which is absorbed and enters the metabolism of the animal. High intake of animal and dairy products favor high levels of fatty acids such as nonadecanoic acid.

Alternatively, it is possible that the bacteria in the human gut could produce sufficient amounts of propionate to lead to elevation in the odd-carbon fatty acids. This would only occur under conditions of significant gut dysbiosis.

Carnitine is required for fatty acid oxidation. In carnitine insufficiency, fatty acids are oxidized via an omega oxidation pathway that creates odd chain units. Therefore, odd chain fatty acid accumulation may indicate carnitine deficiency and the need for carnitine supplementation.

The odd numbered fatty acids containing 15, 17, 19, or 21 carbon atoms (heptadecanoic acid, nonadecanoic acid, tricosanoic acid, pentadecanoic acid) accumulate in vitamin B12 deficiency.

Possible treatment:

– Follow a whole foods plant-based diet.

– Vitamin B12

– Carnitine

References:

https://www.gdx.net/core/interpretive-guides/Fatty-Acids-IG.pdf

Disclaimer:

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.