Biomarkers

What is Beta-Carotene (Genova)? High and low values | Lab results explained

Beta-Carotene is an oxidative stress marker.

beta-carotene high low meaning symptoms vitamin a genova lab results optimal ranges sources carrots

– Beta-Carotene is involved in antioxidant protection.

– Beta-carotene is converted into vitamin A in the liver.

– Beta-carotene & other carotenoids are converted to vitamin A (retinol), involved in vision, antioxidant & immune function, gene expression & cell growth.

– The absorption of beta-carotene and its conversion to vitamin A varies among individuals.

– The most well studied carotenoid is beta-carotene.

– Carotenoids are the plant sources of vitamin A.

– A single beta-carotene is converted to 2 molecules of vitamin A.

– Of all the carotenoids, beta-carotene is converted into retinol most efficiently.

– Supplementation with beta-carotene is a safer alternative than vitamin A.

– The conversion of beta-carotene (provitamin A) to vitamin A (retinol) is accelerated by thyroxin and is increased in hyperthyroidism.

Beta-Carotene has antioxidant and other roles independent of vitamin A. Body pools of the two compounds are maintained independently so that, unless vitamin A levels are initially low, increased intake of beta-carotene may not affect higher levels of vitamin A.

Blood concentrations of carotenoids are the best biological markers of fruit and vegetable consumption. A large body of epidemiological evidence suggests that higher blood concentrations of β-carotene and other carotenoids obtained from foods are associated with lower risk of several chronic diseases.

Because vitamin A is a fat-soluble vitamin, GI conditions affecting the absorption of fats (cystic fibrosis, pancreatic insufficiency, IBD, or small-bowel surgery) may decrease the vitamin A absorption. Patients with low vitamin A levels may have an increased risk of respiratory infections or infertility issues. If you have low vitamin A levels, a check of fatty acid levels is advised.

Supplementation with alpha-tocopherol or beta-carotene does not prevent lung cancer in older men who smoke. 

Sources of beta-carotene:

– Carrot

– Pumpkin

– Sweet potato

– Spinach

– Kale

– Turnip greens

– Beet greens

Lower values:

Increase consumption of beta-carotene containing whole foods.

Sources of beta-carotene:

– Carrot

– Pumpkin

– Sweet potato

– Spinach

– Kale

– Turnip greens

– Beet greens

Higher values:

Decrease consumption of beta-carotene containing food sources.

Is your Vitamin A level low while your beta-carotene level is high?

People with low thyroid function may have a slowed conversion of beta-carotene to vitamin A, and thus have a profile as shown here, with an elevated beta-carotene and low vitamin A:

beta carotene genova

In such a situation it may be warranted to consider a thyroid function, which can also be influenced by tyrosine and iodine levels.

References:

– Antioxidants in health and disease: overview. [L]

– Effects of 4 y of oral supplementation with beta-carotene on serum concentrations of retinol, tocopherol, and five carotenoids. [L]

– Beta-carotene, vitamin A and carrier proteins in thyroid diseases [L]

– The status of retinoids in women suffering from hyper- and hypothyroidism: interrelationship between vitamin A, beta-carotene and thyroid hormones. [L]

– National Institutes of Health Office of Dietary Supplements: Vitamin A Fact Sheet for Health Professionals  [L]

– Beta-Carotene Is an Important Vitamin A Source for Humans [L]

– High-serum carotenoids associated with lower risk for developing type 2 diabetes among Japanese subjects: Mikkabi cohort study [L]

– Diet and Bladder Cancer: A Meta-analysis of Six Dietary Variables [L]

– alpha-Tocopherol and beta-Carotene Supplements and Lung Cancer Incidence in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study: Effects of Base-line Characteristics and Study Compliance [L]

Disclaimer:

The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.

%d bloggers like this: