What is F2-Isoprostane/Creatinine? High and low values | Lab results explained

The F2-isoprostane/creatinine ratio is the “gold standard” for measuring oxidative stress and has utility in individuals who have lifestyle risks due to poor diet or smoking, a family history of cardiovascular disease, or hyperlipidemia.

F2-IsoPs are compounds formed from arachidonic acid. Arachidonic acid is required by your body to make muscles and for basic functioning. Your body can make arachidonic acid on its own, or can get it from the foods you eat, such as red meat or egg yolks. As with many things, having too much or too little arachidonic acid can be harmful to the body. Having too much arachidonic acid can increase the production of F2-IsoPs which can damage the body’s tissues and therefore contributes to the onset of chronic disease.

F2-IsoPs can cause blood vessels to constrict, which may raise your blood pressure, and promote blood clotting resulting in a heart attack or stroke. In support of this, F2-IsoPs may be elevated at the earliest stages of plaque development in your arteries. Research has shown that people with high levels of F2-IsoPs are 30x more likely to develop heart disease.

– Elevated urinary F2-Isoprostanes are associated with an increased relative risk of coronary heart disease (CHD).

– High levels are seen in conditions associated with increased risk of atherosclerosis and certain cancers.

What can I do to help lower my F2-IsoPs levels?

Because F2-IsoPs are known as “lifestyle” markers, their levels are affected by lifestyle choices you make, such as what you eat and how much you exercise. Therefore, you can make changes in your daily life which can lower your F2-IsoPs to safe levels: 

– Reducing the amount of red meat and increasing the amount of fruit and vegetables you eat can help lower your F2-IsoPs levels.

– Your F2-IsoP levels may also be lowered by increasing the amount you exercise.

– If you smoke, you should consider stopping as smoking also increases F2-IsoPs levels.




This test is performed by a Liquid Chromatography-Tandem Mass Spectrometry (LC/MS/MS) method. This test was developed and its performance characteristics determined by the Cleveland HeartLab, Inc. It has not been cleared or approved by the U.S. FDA. The Cleveland HeartLab, Inc. is regulated under Clinical Laboratory Improvement Amendments (CLIA) as qualified to perform high-complexity testing. This test is used for clinical purposes. It should not be regarded as investigational or for research.

Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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