8-hydroxy- 2’-deoxyguanosine (8-OHdG) is a byproduct of oxidative damage to guanine bases in DNA.
It is used as a biomarker for oxidative stress and carcinogenesis. It has been studied to estimate DNA damage after exposure to carcinogens including tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.
8-OHdG levels are positively associated with markers of inflammation and evening cortisol, indicating that increased physiological or psychosocial stress is associated with increased oxidative damage.
WHAT DOES IT MEAN IF YOUR 8-OHDG (URINE) RESULT IS TOO HIGH?
Elevated 8-OHdG indicates oxidative damage to DNA. Diseases including cardiovascular disease, Chronic obstructive pulmonary disease (COPD), cancer, thyroid disease, and diabetes have been associated with excessive concentrations of 8-OHdG.
Minimizing exposure to xenobiotics and cigarette smoke, stress management, and increasing antioxidant intake may prevent further oxidative damage.
Increased physical activity is associated with a reduction in urinary 8-OHdG levels.
Green tea catechins decreased 8-OHdG concentrations in patients with Alzheimer’s disease.
Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you.
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