What is S100A12? High and low values | Lab results explained

Fecal S100A12 (also called EN-RAGE or calgranulin C) is another inflammatory marker that is highly specific to inflammatory bowel disease such as Ulcerative Colitis and Crohn’s disease and is often used as a noninvasive screening test for these conditions. [L]

Fecal S100A12 is a novel noninvasive marker that has been shown to distinguish active IBD from healthy control subjects in certain populations. S100A12 levels were evenly distributed throughout fecal samples and were stable for 7 days when stored at room temperature. Fecal S100A12 was shown to be elevated in children with IBD compared with healthy control subjects, with levels closely correlated to disease activity and other serum inflammatory markers, particularly lower gut involvement. [L], [L]


Sidler MA, Leach ST, Day AS. Fecal S100A12 and fecal calprotectin as noninvasive markers for inflammatory bowel disease in children. Inflamm Bowel Dis. 2008 Mar;14(3):359-66. doi: 10.1002/ibd.20336. PMID: 18050298. [L]

Fecal S100A12 is a promising noninvasive marker for pediatric IBD. Nat Rev Gastroenterol Hepatol 3, 481 (2006). [L]

Alexandre Carvalho, Jacky Lu, Jamisha D. Francis, Rebecca E. Moore, Kathryn P. Haley, Ryan S. Doster, Steven D. Townsend, Jeremiah G. Johnson, Steven M. Damo, Jennifer A. Gaddy, “S100A12 in Digestive Diseases and Health: A Scoping Review”, Gastroenterology Research and Practice, vol. 2020, Article ID 2868373, 11 pages, 2020. [L]


S100A12 is highly abundant in neutrophils during acute inflammation and has been implicated in immune regulation.

S100A12 is implicated in gastroenteritis, necrotizing enterocolitis, gastritis, gastric cancer, Crohn’s disease, irritable bowel syndrome, inflammatory bowel disease, and digestive tract cancers.

S100A12 is an important molecule broadly associated with the pathogenesis of digestive diseases. [L]


Test results may vary depending on your age, gender, health history, the method used for the test, and other things. Your test results may not mean you have a problem. Ask your healthcare provider what your test results mean for you. 

The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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