Protein in the serum is made up of albumin (∼ 60%) and globulin.
Globulins are divided into alpha-1, alpha-2, beta, and gamma globulins.
Globulins are made in your liver by your immune system. They play an important role in liver function, blood clotting, and fighting infection.
In general, alpha and gamma globulin protein levels increase when there is inflammation in the body.
Normal ranges for Alpha-1 globulin are:
Increased alpha-1 globulin proteins may be due to:
- Acute inflammatory disease
- Chronic inflammatory disease (for example, rheumatoid arthritis, SLE)
- Cancer
Decreased alpha-1 globulin proteins may be due to:
- Alpha-1 antitrypsin deficiency (a genetic disorder that may result in lung disease or liver disease)
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