What is Alpha-1-Globulin, Serum?

Protein in the serum is made up of albumin (∼ 60%) and globulin.

Globulins are divided into alpha-1, alpha-2, beta, and gamma globulins.plasma proteins albumin globulin alpha-1 fibrinogenGlobulins are made in your liver by your immune system. They play an important role in liver function, blood clotting, and fighting infection.

In general, alpha and gamma globulin protein levels increase when there is inflammation in the body.

Normal ranges for Alpha-1 globulin are:

alpha-1 globulin protein serum test scorecard high low meaning reference range values optimal

Increased alpha-1 globulin proteins may be due to:

  • Acute inflammatory disease
  • Chronic inflammatory disease (for example, rheumatoid arthritis, SLE)
  • Cancer

Decreased alpha-1 globulin proteins may be due to:

  • Alpha-1 antitrypsin deficiency (a genetic disorder that may result in lung disease or liver disease)


The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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