What is Glutamic Acid (Genova)? High and low values | Lab results explained

Glutamic acid (or Glutamate) is a major mediator of excitatory signals in the brain and is involved in most aspects of normal brain function including cognition, memory and learning.
– Glutamic acid is a non-essential amino acid.
– Glutamic acid is also referred to as glutamate.
– It is used in the biosynthesis of proteins.
– Glutamic acid functions as an excitatory neurotransmitter in the central nervous system and is important in removing ammonia from the brain.
– Glutamic acid is the most common excitatory neurotransmitter in the central nervous system.
– It also regulates appetite, cognition/learning/memory, increases gut motility, improves libido and decreases sleep

Lower levels:

– Low glutamic acid levels indicate ammonia toxicity, with symptoms including headache, irritability, and fatigue, especially if high glutamine. Low protein, high complex carbohydrate and B6, á-KG and BCAA’s suggested to correct ammonia toxicity.
Disorders possibly related to low glutamate in urine:
– Agitation
– Chronic fatigue
– Depression
– Insomnia
– Lethargy
– Migraines
Other possible symptoms:
– Fatigue
– Poor brain function
– Poor memory

Higher levels:

Higher glutamic acid levels suggest possible under-conversion to á-KG in liver for use in citric acid cycle. Supplement niacin and B6.

Disorders possibly related to high glutamate in urine:

– Anxiety
– Autism
– Bipolar disorder
– Celiac disease
– Depression
– Hyperthyroidism
– Insomnia
– Panic
– Stroke

Other possible symptoms:

– Neurotoxicity
– Stress, anxiety
– Low mood
– Sleep disturbances


The information on is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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